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Cyclozygenase (Cox) inhibitors include all the anti-inflammatory drugs including aspirin, ibuprofen (Advil), naproxen (Aleve), and celecoxib (Celebrex). Vitamin B6 is absolutely critical for hundreds of necessary chemical processes including detoxification, making and clearing neurotransmitters, and on and on. The good news is that there are many natural cox inhibitors which do not have the same problems. More to the point, pain is an important message. Short term pain relief can be important but it is much better to find the cause. Chiropractic is often ignored by the medical profession but it has been shown to be one of the most effective treatments for many acute and chronic pain syndromes. In my practice I frequently find inflammation will increase pain. And by far the most common cause of general inflammation starts in the gut. Taking NSAID’s causes gut inflammation creating a negative loop. NSAID use is said to be responsible for 16,000 deaths in the United States every year. There are better solutions but that often requires a holistic approach looking at all the factors that are causing immune activation: diet, stress, joint and nerve, and genetic issues. Personally, and with many patients, I use the traditional herb, Boswellia, for inflammation.

Clinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolism.

Am J Clin Nutr.2013 Dec;98(6):1440-9. doi: 10.3945/ajcn.113.064477. Epub 2013 Oct 23.

Long-term physiologic doses of cyclooxygenase inhibitor may impede the synthesis of the coenzymatically active form of vitamin B-6. Because the cause of vitamin B-6 depletion in inflammation remains unknown, this study provides a potential mechanism that could account for the poor vitamin B-6 status in human inflammation. Moreover, this study further raises concerns about the long-term clinical use of antiinflammatory NSAIDs in humans. Vitamin B-6 status should be carefully monitored in long-term NSAID users. Future randomized placebo-controlled studies are needed to determine the impacts of antiinflammatory cyclooxygenase inhibitor use on vitamin B-6 metabolism in humans. https://www.ncbi.nlm.nih.gov/pubmed/24153347 

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